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Best Diaper Rash Cream

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Diaper rash affects almost all babies and toddlers before the age of 3 years old. Diaper rash typically begins as a red, irritated rash in the diaper area. Triggers of diaper rash include irritation, wet diapers left on too long, too many poops, loose poops (from sickness or from taking antibiotics), and diapers that are too tight and small. If the early diaper rash phase is left untreated, then the diaper rash can progress and result in an overgrowth of yeast that appears as satellite red bumps and pustules surrounding a juicy red rash.

Using the best diaper rash cream or ointment early can help sooth diaper rash and prevent it from worsening to a case of diaper rash that needs a visit to the pediatrician or dermatologist.

When deciding what the best diaper rash cream or ointment is to use on your baby, consider the situation, the type of diaper rash, and the ingredients.  

Situation #1:

  • Let’s prevent diaper rash! Diaper rash can be prevented by protecting baby’s bottom. Application of an ointment such as Baby Pibu’s Hydrating Ointment with every diaper change can provide a protective layer between baby’s skin and the elements (pee and poop). For longer naps and overnight sleep, application of an ointment with zinc oxide is recommended as zinc oxide provides further physical protection for baby’s skin against the elements. For this, Baby Pibu’s Bottom Balm can be used. If there are any initial signs of redness or irritation in the diaper area, begin using Baby Pibu’s Bottom Balm as well with every diaper change.

Situation #2: Blissful Bottom Gift Set

  • Spot and soothe diaper rash! When red bumps or pustules appear along with the redness in the diaper area, your baby has developed full blown diaper rash with secondary candidiasis (yeast). When this happens, increase the frequency of diaper changes and make sure the diapers aren’t too tight. You may want to let your baby’s bottom breathe by letting your baby go diaperless for short periods of time. In addition, using a warm washcloth instead of a wipe may be less irritating and more soothing. You can apply Baby Pibu’s Intensive Bottom Relief. This diaper rash ointment has thymol (natural anti-bacterial and anti-fungal) and cornstarch to help relieve the rash.
  • During a full-blown case of diaper rash, you may also have to use an anti-yeast medication. OTC topical Lotrimin AF cream with clotrimazole and similar “-azole” anti-yeast agents can be mixed in Intensive Bottom Relief or another diaper rash cream if needed. When shopping for an OTC anti-fungal medication, make sure you pick one with an active ingredient ending in “-azole.” For example, OTC Lamisil will not work since it does not have good yeast coverage.


  • The best diaper rash creams are typically creams or ointments. Creams and ointments are formulations with more oils and less water. Products like lotion have more water, and water actually draws out the natural water and moisture from the skin.
  • The oils that you will find in the best diaper rash creams include petrolatum, calendula oil, lanolin, sunflower oil, and beeswax. Since it is not viewed as natural, petrolatum catches a lot of grief. Petrolatum is the one “oil” that cannot cause any further irritation or allergic reaction. If you choose a product with a natural oil, consider that the ingredients may be causing more irritation if the diaper rash is not getting better.
  • Zinc oxide is a key ingredient to look for in the best diaper rash cream as it provides an extra physical barrier of protection from the pee and poop elements. Zinc oxide also allows the skin a chance to heal.

Happy hunting for the right and best diaper rash cream. Just remember the situation you are choosing it for- prevention versus treatment. Consider the ingredients as well as certain ingredients will allow for a case of diaper rash to heal more quickly.